Hi,
It sounds like the Remote Desktop session is disrupting your touchpad driver, which is why it only works again after restarting. You can also try this , update your touchpad and HID drivers through Device Manager, as outdated drivers often cause this kind of behavior. Then, right-click your touchpad in Device Manager, go to Properties > Power Management, and uncheck "Allow the computer to turn off this device to save power" so Windows doesn’t disable it after Remote Desktop use. You can also reinstall the official touchpad driver from your laptop manufacturer’s website to replace any corrupted or incompatible files. If you’re using Windows Pro, open gpedit.msc and review Remote Desktop’s device redirection settings to ensure input devices aren’t being restricted after disconnection.
Kind regards,