Processes in Microsoft 365 for setting up Office apps, redeeming product keys, and activating licenses.
Hi @Ross A
Thank you for reaching out to the Microsoft Q&A Forum.
I understand you are in an incredibly frustrating and stressful situation. Being completely locked out of your Microsoft 365 Business account is a critical issue that brings everything to a halt. The error code 500121 occurs when authentication failed as part of the multi-factor authentication (MFA) request, it may indicate a configuration or service error. Please find below a few steps that may help resolve the issue:
Because you are the only Global Administrator and you are completely locked out from the tenant. You may consider using the 24/7 support service available through Microsoft 365. You can initiate a support request by starting a free trial here: Microsoft 365 Business Plans and Pricing | Microsoft 365
Assuming that you have already created an account after registering a free trial and you can go to Microsoft 365 admin center and click "Help & support" icon to raise your ticket. The agent will be able to create a ticket for you under the affected tenant and then transfer this ticket to Data Protection team who could help you to regain access.
You can follow this link for more instructions: Get support - Microsoft 365 admin | Microsoft Learn . With this solution, you might be able to regain access to your admin portal in the old tenant. This will allow you to reassign MFA to your current device.
We hope the details provided will assist you effectively.
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