Run a full Online Repair of Microsoft 365 or Office because the screenshot shows PowerPoint itself failing during startup, rather than an error identifying one particular presentation.
Repair PowerPoint on Windows 11
- Close PowerPoint and all other Office applications.
- Right-click Start → Installed apps.
- Find Microsoft 365 or Microsoft Office.
- Select the three dots (…) → Modify.
- If shown How would you like to repair your Microsoft 365 and Office programs?, choose Online Repair → Repair.
- If yours is an MSI-based Office installation, choose Repair → Continue instead.
- Complete the repair, restart Windows if requested, and then open PowerPoint without selecting a presentation.
Online Repair is more thorough than the Repair Now button in the error dialog or Quick Repair, and it repairs the whole Office suite even when only PowerPoint is affected.^1^
If Online Repair does not fix it
Test PowerPoint without add-ins:
- Press Windows key + R.
- Enter:
powerpnt.exe /safe
- Select OK.
- If PowerPoint opens in Safe Mode, go to File → Options → Add-ins.
- Beside Manage, select COM Add-ins → Go.
- Clear all checkboxes and restart PowerPoint normally.
- If it now works, re-enable add-ins one at a time, restarting PowerPoint after each one, to identify the conflicting add-in.^2^
If PowerPoint opens but only some presentations fail
That points to a problem with those files rather than the PowerPoint installation. Try recovering each affected file:
- Open PowerPoint to a blank presentation.
- Select File → Open → Browse. Do not select the file from Recent.
- Select the affected presentation once.
- Select the arrow beside Open → Open and Repair.^3^
- If it opens, immediately save a new copy under a different filename.
If PowerPoint instead reports “Can’t read file” or “Presentation cannot be opened,” right-click the file in File Explorer → Properties. If an Unblock option appears, select Unblock → Apply → OK, and try opening it again.^4^
If Online Repair fails and PowerPoint also crashes in Safe Mode before opening a blank presentation, the next step is to uninstall and reinstall Microsoft 365/Office. Before uninstalling, confirm that the license or subscription is associated with the Microsoft account used to install Office.
References
- Repair an Office application
- PowerPoint isn't responding, hangs or freezes | Microsoft Support
- Open a document after a file corruption error | Microsoft Support
- Error: Can't read file, or Presentation cannot be opened | Microsoft Support