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Thank you for posting here in the Microsoft Community. I understand that you are having issues using the Microsoft Natural Ergonomic Keyboard 4000 on Windows 11. The existing file remnants you encountered point to a corrupted MSI Windows Installer database registry cache, rather than normal file folders or standard registry entries. To make sure we completely bypass that stubborn installer loop and get your keyboard fully functional, could you let me know what specific tool or method you used to scrub the registry? Also, have you already tried using the official Microsoft Program Install and Uninstall Troubleshooter?