Hi J Pick,
Based on what you shared, since the shortcuts and right-click commands work in other Microsoft programs, this is isolated to Excel 2016. Because Safe Mode did not restore the commands, please try these steps next:
1/ Repair Office
- Close all Office applications (Word, PowerPoint, Excel, Outlook, etc.).
- Open Settings (or press Windows + I) > go to Apps > Installed apps.
- Find the Office 2016 package > select the three dots (…) next to it and choose Modify.
- If prompted by User Account Control, select Yes.
- Run Quick Repair first. If the problem persists, run Online Repair later.
Note: if you're using Windows 10, there is no three dots option. In Windows 10, go to Settings > select Apps and Features > select the Office product and then select Modify.
For reference: Repair an Office application | Microsoft Support
2/ Reset Excel's registry configuration
- Press Windows key + R > type regedit > OK to open Registry Editor
- Navigate to this path
HKEY_CURRENT_USER\Software\Microsoft\Office\16.0\Excel
- Right-click the Excel key and rename it to Excel.old
- Close Registry Editor and restart Excel. It will create a fresh configuration key.
- Test the shortcuts to see if it works properly now.
Hope this will help. Should you have any other questions, please feel free to share them in the comments on this post. I'm happy to assist you further.