Hi Mike Smith,
Since these documents were created with a much older version of Word, Office 2007 may be preventing some legacy file formats from opening because of its File Block/security settings.
Before making registry changes, I’d recommend checking the file type and the Trust Center settings first. If you can successfully open a document in Word 2007, immediately save a copy in the newer Word format (.docx). This is the safest approach for making the documents easier to use with newer Word versions.
I would avoid adding a broad Trusted Location or disabling security protections unless necessary. Trusted Locations bypass File Block and other security checks, so they should be used only for files from a source you trust. (Trusted Locations for Office files)
If you can share the file extension of one of the old documents (for example, .doc) and the exact message Word 2007 displays when you open it, that should help determine whether File Block is actually responsible and whether any specific setting needs to be changed.