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Hi AV,
A tenant that can't send any outbound email is a serious disruption. You've already done the main containment work, which will help the review. Unfortunately, as a forum moderator, I am not able to review your tenant or remove the restriction directly. My role here is limited to providing general guidance you can apply from your side. Error 550 5.7.705 is a tenant-level block. It applies to the whole organization, not to a single user. That's why Restricted entities in Defender can be empty while the tenant still can't send mail.
As for your first question, whether the block can be lifted automatically, I'd recommend not counting on that. Microsoft's guidance for this error is to fix the underlying cause first and then contact Microsoft Support to have the block removed.
On your second question, about what to remediate before contacting support, Microsoft lists two common causes of this block: a compromised admin account used to create connectors, and a compromised on-premises server that routes mail through Exchange Online. Besides what you've already done, I'd recommend:
- Checking Mail flow > Connectors in the Exchange admin center for any connectors you don't recognize
- Reviewing inbox rules and forwarding on the compromised mailbox, and on any admin accounts
- Making sure every admin account has completed MFA registration, then following up on the users who haven't
Once you've finished, open a service request from the Microsoft 365 admin center. Include the NDR, the Defender alert, and a summary of the remediation you've completed. For detailed instructions on how to get support, please refer to Get support - Microsoft 365 admin.
For reference: NDR error codes 550 5.7.703, 550 5.7.705, 550 5.7.708, and 550 5.7.750 | Microsoft Support
I hope this helps you get outbound mail running again soon. Should you have any further questions or need additional assistance, please don't hesitate to reach out. I'm always happy to help. Have a wonderful day!
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