Hi BOB TERRAZAS,
Thanks for the details.
Could you please confirm the Windows version and build shown in winver the latest KB listed under Windows Update > Update history, and whether Ctrl + Shift + Esc still opens Task Manager? Also, does the problem continue with the second monitor or dock disconnected?
If Task Manager opens, select Windows Explorer under Processes, then choose Restart task. The desktop and taskbar may briefly disappear while they reload.
Next, press Windows key + Ctrl + Shift + B once to reset the graphics driver. A brief flicker or beep is normal. Then check whether the icons and menus respond again.
If the issue remains, please test Safe Mode with Networking from Troubleshoot > Advanced options > Startup Settings > Restart, then press 5 or F5. If everything works there, a driver or background program may be interfering.
Let me know what you find and I’ll help narrow down the next step.