If the Tamper Protection setting is greyed out, it is usually being controlled by a policy, third-party antivirus product, or a registry/group policy setting rather than Windows Security itself.
Check whether:
- A third-party antivirus is installed.
-
DisableAntiSpywareor related Defender policies exist in the registry. - Group Policy settings under Windows Defender Antivirus are configured.
You can also run:
Get-MpComputerStatus | Select IsTamperProtected
and post the result. That will help determine whether Tamper Protection is actually disabled or being managed by another setting.